If you are to believe the JBL TS sheet the 2220 is way better. The only thing that the E145 has thats better is lighter cone. The 2220 has higher fs, lower q, lower LE and way highter BL. As a matter a fact the E145 doesnt look like a very good horn loading candidate at all looking at those specs. In theory that is, in practice it might be another matter.
Dr.db
I think it would be better if you built your own mid bass horns and worked out another solution for the sub 100Hz frequencies.
Maybe something like this? This guys homepage was a catalyst for my own project startup.
http://www.volvotreter.de/index.htm
/Mostly