Yes, I still use them with 2482 and 2350 as in the last image in the link.
With a minidsp 4x10 its easy to try different setups. I would try both with and without the 2405. I probably would use it but it might come down to personal preferences. Depending on the horn you are going to use with the 4001 or 2446 I think you might get better dispersion in the higher register using the 2405. (what horn are you going to use? havent seen it anyware but I might have missed it)
I think you have to let the 18" go higher to be able to use a 10". The 12" should work better if you want to cross the low mid at 60. Unfortunately I have no experience with the 2206 so I cant comment on detail.
If you are going to use the lows in separate boxes you might aswell first go with seperate enclosures all the way initially to figure out what setup you like
like this guy.
Just my 2c
/Mostly