In my experience a notch that narrow and deep is usually due to a "bounce" somewhere. Since you get it at different distances, it is probably not a floor bounce. The obivous question (and you probably already know this) is whether there is a hard surface about 2-4 inches from the mic.
I have measured 2446's mounted on tractrix horns (Klipsch) and CD horns (Electro-voice HP series) and I have not seen that behavior.
Just an oddball possibility, is the seal between the driver and horn nice and snug (is there a gasket)?
BTW, I am a fan of the 2446. It is a great driver, but you need to stay from after-market diaphragms.
-Tom